Background: Strengthening nurses' cognition to breast cancer and breast cancer screening not only positive impact their family members, but also influence to the implementation of the public health guidance. Purposes: To investigate the nurses breast cancer's cognition and influencing factors. Methods: A regional hospital 100 nurses in northern Taiwan were chosen as sample size. This research started from September 1, 2014, and ended to January 31, 2015. Self-developed structured questionnaires for breast cancer cognition and breast cancer screening were used as a tool. SPSS 21.0 software was used to analyze the data. Observer's reliability was 0.8. Experts' validity and content validity were used. Results: The total average score were 4.05 on breast cancer cognition, in which the clinical symptoms of breast cancer cognitive scores were the highest, 4.21; the second were cognitive therapy for breast cancer, the average was 4.17; the third were awareness of breast cancer's definition 4.01; the last were high risk factor for breast cancer awareness, 4.00. Cognitive breast cancer screening, the average score was 3.95 . Nurse's age, marital status, education, religion, reproductive status, health status, financial support, breastfeeding experience, taking medicine, family history and whether there had undergone breast cancer screening were significant differences to breast cancer's cognition. Regression Analysis showed that fertility status, breastfeeding experience, ever received breast cancer screening; religious, economic support, health status, marriage, and education, these independent variables could explain 57.8% of variance. Conclusions/Implications for Practice: The study not only could elevate nurses' self-efficacy on breast selfexamination screening, but also could improve health education for patients with high rates of breast cancer screening. This help to achieve the effect of early prevention and the goal of early treatment.