In order to improve the quality of cancer care, the case management model was adopted in an South Medical Center at 2003. The information system for cancer case management was designed at 2008. The purposes of this study were assessing the effects of cancer case management information system. Primary data was collected from the cancer case managers by executing the questionnaire and interviewing. Then the data was analyzed by using SPSS software 12.0. Cronbach's α was >0.9 at the questionnaire for needs of cancer case management information system. The overall satisfaction rate for cancer case management information system was 42.9%. The cancer case managers suggested that hospital information system plan should including cancer case management information system. From this study, the questionnaire, experience and study results were as the preliminary reference for someone who want develope case management information system in the further.