This article is a describes nursing experience of treating young men with positive attitudes and their family members facing the progress of diseases and uncertainty in life caused by various complex physical and mental problems. The study period was from July 01 to 13, 2016. Based on observations and interviews, a four-level assessment of the patients' physical, psychological, social, and spiritual conditions was conducted to confirm whether the patients experienced pain, physical symptoms, or mental distress. The nurses faced many problems, including the initial expectation that family members would feel sad. Based on physical assessments and the pain scale, analgesic drug prescriptions were adjusted and supplemented by individual care to alleviate the symptoms of physical discomfort. The nurses coordinated with the medical team to offer listening and companionship services to guide patients and their families in discussing their feelings. Life reviews were conducted to analyze patients' self-integration and healing, thereby providing peace of mind to the patients in the face of such dismay. Furthermore, family members were guide to complete the patients' wishes and prepare for their funerals so that there would be no regrets. Finally, because of the peace of mind facilitated by the care provided by the team, patients and family members could make all relevant decisions about each patients' end of life care in a timely manner. We hope that these experiences can be shared to serve as references for clinical end of life care.