In this paper, the earthquake-resistancy of a four-story RC school building with various construction systems are analyzed compared. The comparison shows that the seperated-breast-wall system, the column spacing adjusted form usual 5m to 3.3m system, the maximum principal axis of the columns adjacent to the classroom partition wall turned 90° system, and the school building with corridor columns can abtain higher system collapse acceleration and absorb more seismic energy. Also, they will reduce the structural damage during earthquake excitation. For the system with column-edge-wall, the collapse acceleration will be improved too, however, the ductility of the system will be affected.