The aim of this paper is to analyze the challenges and development of the ASEAN states while entering the era of new century. Also, it is to study how the ASEAN states solve and break through the financial crisis, and recover their economies, in turn, promote their politico-economic status in the Asia-pacific region. There are four crucial parts in this paper. The first is to analyze what challenges the ASEAN states have faced for the changing economic order in the Asia- Pacific. The second is mainly focused upon what problems the ASEAN states have encountered as the Asia-pacific political order has been changing. The third is to check what the ASEAN states are supposed to do, and how they adjust policies and respond for those changes. Finally, conclusion and prospect will be made, especially the forward development of the ASEAN states in 21st century will be evaluated.