My study in “Embodying the Posthuman: Disability, Biotechnology, and New Materiality in Contemporary Cultural Representations” explores Rosi Braidotti’s three distinctive configurations of posthuman embodiment—life beyond the self, species, and death—in modern film, literature, and cultural representations. Katherine Dunn’s Geek Love (1989), Andrew Niccol’s Gattaca (1997), and Margaret Atwood’s Oryx and Crake (2003) are all literary works that focus on the prosthetic potentials and possible effects of biotechnology in order to explore the human animal’s entanglement with posthuman environments. Moving beyond the trepidation and excitement brought on by recent advances in genetic engineering and bionic prostheses, these works not only expose biotechnology’s roots in twentieth century biopolitical and disability studies, but also anticipate new forms of social subjectivity. While these works represent a diverse range of literary vision, all locate the material body as a prosthetic site of convergence for technology and posthuman becoming. Drawing upon the interdisciplinary efforts of posthumanist scholarship and disability studies in interrogating enhancive technologies as well as discerning the subsequent social impact, my research centers on the prominent themes of biotechnologically altered bodies, the commodification of disabled body matters, and marketing enhancive treatments as an alternative for abject bodies in our contemporary, using various representations of the prostheses as an organizing trope. Taken together, I argue that a technocapitalist approach to bio- and prosthetic technologies furthers the social construct of disability by allowing physical differences to reflect a widening gap in technological power, consumer capacity, as well as individual access to enhancive treatments. The effects of biotechnology are not only reflected on the human species, but also configure heavily in the advance of artificial intelligence, which I will further explore in the discussion of affective embodiment and new materiality in Alex Garland’s Ex Machina (2015). Taking Braidotti’s thoughts on posthuman life after theory as a point of departure, I will conclude by discussing future possibilities in posthuman bodies, interdisciplinary education, and the humanities.