The primary purpose of this descriptive correlative study was to understand the sources of nurses' work stresses, responses, and related factors when caring for post-liver transplant patients. Forty-one female register nurses (RNs) who had participated in post-transplantation care were recruited to participate in this study. "Patient's condition" and "political factor" were the major sources of stress. There was a negative relationship between age and "work load" and between professional working experience and "work load". Nurses who had intensive care unit training had lower "un-realistic self expectation". The overall level of stress was mild to moderate. The sources of stress and responses showed a significant positive correlation. Finally, the major predicative variables that influenced the stress responses were "political factor" and "age". These accounted for 43.7% of the variance.