Business process reengineering is used to increase the competitiveness among the fast growing environment and the high technology world nowadays. There are many business process reengineering theories and many successful cases, but when business come to the real reengineering part many problems and difficulties arise as most of the enterprises do not know where to start the business reengineering and what place to improve or solve the problems/difficulties. In this research we focus on multiple-gain management principle's assumptions. In order to gain the multiple beneficial results, we investigate whether those assumptions could be changed by the environmental factors or the development of information technology (such as computers replace manual), so the purpose of the business process reengineering can be fulfilled. This paper quotes three multiple-gain management principles: Pareto principle (gained 5 times of benefit), separation of responsibility (gained double times of benefit) and centralization/decentralization (gained many times of benefit). The paper will aim the enterprises to find out where to start the business process reengineering and to exam the management principles mentioned above by creating a set of examine table. Meanwhile, case studies will be discussed in order to proof the research practicability and to supply enterprises to look for the business process reengineering model best suited to their needs.