This study attempts to investigate the relationship among the non-performing loan (NPL) ratio of the banking industry and several macro economic factors in Taiwan. The ordinary least square method is employed in determining the regression model. Results of this study do not only show that the unemployment rate, economic growth rate, inflation rate, the index of real estate market prosperity and the interest rate spread are significantly related to the NPL ratio, but also suggest that banks should pay more attention to borrowers’ ability and sources of payments as well as the value of collaterals.