During the economic development in Taiwan, the small-medium businesses (SMBs) played important rules and established the economic foundation. Due to the difference of operational mechanism from the large industry, the SMBs encountered some difficulties to obtain the financing loans from financial institutions. This study intends to examine the factors of financial, non-financial and borrowers’ characteristics that may cause the SMBs to default. We collected SMB samples from one financial institution in central Taiwan, and conducted the Logistic Regression model for empirical analysis. Results indicate that the economic growth ratio, whether the business provides the guarantees or not, the term of loan, the education levels of borrowers, and previous records of default are significant to the default behavior of SMB loans.