Issues with respect to the application of regional trade and the Agreement on Safeguards remain to be clarified, given the lack of clear guidelines in GATT Article 24, Article 19 and the Agreement on Safe-guards. The aim of this paper is to identify how WTO members that are also members of regioinal trade agreements (hereafter RTA) should apply safeguards in line with WTO rules. The essential questions that this paper tries to address include whether RTA members could apply safeguards for each other within intra-trade, whether RTA members may be allowed to be excluded from the application of global safeguard measures, as well as whether bilateral safeguard measures applied specifically for intra-trade are exceptions to the Agreement on Safeguards. In section two, the general overview of existing safeguard provisions prevalent in the RTA will be addressed by examining various RTA provisions. Section three will present and discuss controversial issues emerging from the RTA and Safeguards. Then in section four, disputed cases involving WTO jurisprudence under the Agreement on Safeguards, including Argentina-Footwear, US-Wheat Gluten, US-Line Pipe and US-Steel Safeguards, will be analyzed. The auhor will provide her comments and views on relevant issues raised in this paper in section five. In the author’s view, RTA members should not be prohibited from applying intra-trade safeguards in fulfillment of the requirment of “substantially all trade” under GATT Article 24. With respect to the application of “parallelism” created by the WTO dispute rulings and the non-discrimination principle required under the Agreement on Safeguards, the possible conflicts existing between these two requirements also need further elucidation. In addition, it is the author’s view that, under proper conditions GATT Article 24 should be regarded as an exception to the Agreement on Safeguards for the purpose of resolving the root problem of the exclusion of RTA members from the application of global safeguards. The legitimacy of bilateral safeguard measures also needs to be established in this regard. In the final section, recommendations for the government will be elaborated, suggesting, inter alia, intra-trade interests, associated legal risks as well as the negative effects of competition on third countries should be taken into account when implementing or gegotiating RTA safeguard provisions.