This report describes the grief reactions of a after delivering a premature baby with trisomy 13. As a participant observer, the primary author provided nursing care and observed the case’s verbal and nonverbal behaviors. All the data were process recorded, and content analysis was employed. The result showed that the grief reactions included shock and denial, anger and envy, bargaining, self-blame and depression, and acceptance. The neonate’s critical condition and therapeutic regimen were explained to the mother. Risk factors and unpredictability of giving birth to a chromosomally abnormal baby are also clarified. The author acted as a good listener, encouraged the mother to express her sentiments and gave her appropriate emotional support. Gradually the mother recovered from suffering and resumed her daily activities.