Vocational interest is one of the targets upon selecting a proper job as vocational counselor. The study aims to understand the vocational interest of Schizophrenic clients, the related activity tendency and preference; based on the results, practical suggestions are provided in order to assist the Schizophrenic clients to return to the community and raise the employment opportunities. Methods: One hundred and twenty-six Schizophrenic clients, who are the participants of the occupational therapy programs at a psychiatric hospital, were the objects of this study; among them, 62 are male and 64 are female. Their average age is 37 years old. ”The thing I like to do” is the study instrument for data collection. Results: 126 objects show the lowest interest at Physical Performing (disregarding their background); objects who graduated from senior high and had no work experience, either single or divorced, are interested in Selling; objects who graduated from college/university and had work experience, married female, are interested in Business Detail; objects who graduated from junior high/elementary schools, male, are interested in Plants and Animals. Conclusions: One hundred and twenty-six Schizophrenic clients show that they have high interest in sales and office works; most of them do not like performance work at all. The researchers hope that this study can be taken as reference for vocational counseling for Schizophrenic clients.