Abstract The purpose of this study is to explore the contents and essence on Heart Sutra in Buddhism The author derives four points of view to describe the contents of Heart Sutra. Namely, the version adopted, the status of Heart Sutra among all Buddhism Literatures, the essence of five derivatives, the related terminology, the concise interpretation of Heart Sutra in paragraphs. Afterwards, the author provides six aspects of discussions on the essence of Heart Sutra.