目的：比較兩種血管性疾病：冠心病患與慢性腎臟衰竭病患的憂鬱及焦慮盛行率、嚴重程度及生活品質是否有所不同。方法：以某醫學中心30 名冠心病患及30 名慢性腎臟衰竭病患為研究對象，依據結構式問卷評量個案，分析憂鬱焦慮程度及生活品質之相關。最後再以SPSS 描述與分析資料。結果：兩組病患均約有40%符合DSM-IV 嚴重憂鬱症；而慢性腎臟衰竭病患生活品質較差；冠心病患則明顯有較高的焦慮指數，兩組病患的生活品質與憂鬱焦慮及衝動等因素均明顯相關。結論：本研究顯示不同的壓力型態或不同的疾病，對合併焦慮及憂鬱的症狀嚴重度及對生活品質的影響有所不同。

Objectives: The present study was designed to compare the prevalence and severity of anxiety and depression, and the quality of life of patients with coronary artery disease and patients with chronic renal failure receiving hemodialysis. Methods: From January to June 2005, 30 inpatients with coronary artery disease and 30 patients with chronic renal failure receiving hemodialysis were recruited into our study in a medical center. The patients were interviewed and severity of anxiety, depression and quality of life were evaluated using semi-structured and self-reporting questionnaires. The data were collected and analyzed with SPSS 13.0. Results: There were 40% of patients who met the criteria for a major depressive disorder. Patients with chronic renal dialysis had significantly poorer quality of life than patients with coronary artery disease. However, the patients with coronary artery disease had significantly more severe anxiety symptoms. Conclusion: The results of our study indicated that all the patients had more depressive symptoms than the general population. It indicated that the comorbidity of anxiety and/or depression, and quality of life were correlated with the patterns of stressors among patients with medical diseases.