Objective: Due to the opinion of making a good health management is better than passive compensation after an injury and disease, we arranged a class of 'Ergonomic Health Management for Preventing Work-Related Injury' to investigate the effects of ergonomic conceptualization on the improvement of occupational safety and health of workers. Methods: We taught 12 participants skills to stretch and strengthen their muscles and to form a regular exercise habit to maintain their physical fitness via a systemically serial class in one hour each day, twice per week and persisting for six weeks. Results: Not only physical conditions of muscle strength, flexibility and pain, but attention ability and satisfaction of quality of life psychologically also were found to be improved of the participants. Conclusion: In order to reduce the prevalence of work-related injuries, we strongly suggest popularizing the ergonomic health programs and practices in each work place.