Background: School-aged children of mothers with cancer face physiological, psychological and social pressures. Few study findings have examined the lived experience of this vulnerable population. Purpose: This study describes the experience of school-aged children of mothers suffering from cancer. Methods: The researchers adopted a phenomenological approach. Purposive sampling enrolled ten school-age children as participants. Participants all had firsthand experience living with mothers suffering from cancer. Results: After data analysis, five major themes emerged. These were: 1) responding to the illness message; 2) coping with separation from their hospitalized mothers; 3) facing changes in the mothers after treatment; 4) altering lifestyles; and 5) worrying about their mother dying or accepting her death. Conclusions / Implications: This study offers primary insights into the experience of school-aged children with mothers suffering from cancer. Findings can assist clinical nurses and teachers to further understand the feelings of this population and better accompany / help them face and adjust to their situation.