Families having fetuses with congenital abnormalities have decreased because of the Genetic Health Law legislated in Taiwan and the generalization of prenatal examination. However, an ethical issue needs to be addressed: healthcare professionals should respect the autonomy of pregnant women or advocate for the right of fetuses to survive with congenital abnormalities. This article critically reviewed law-related, religious, and cultural literatures. In addition, we used Jonsen et al. (2010) addressed "four-box model" and ethical principles to analyze the ethical decision-making process as to whether the mother with conjoined twins should terminate her pregnancy. In conclusion, although health professionals respected the parents' autonomy and did not proceed with pregnancy termination, it was difficult to predict the impacts of having conjoined twins' birth on the family. We provided necessary prenatal and postnatal nursing care for the mother and her fetuses with congenital abnormalities to assure their safety and quality of care.