Improving quality of life (QOL) is a primary goal that everyone wants to pursue in his/her living. According to the definition of World Health Organization (WHO), QOL is "an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. It is a broad ranging concept affected in a complex way by the person's physical health, psychological state, personal beliefs, social relationships and their relationship to salient features of their environment." The QOL of an individual can be revealed by these six factors mentioned in the definition. However, for the special population there is special issues concerning to their QOL which bring special impact of factor to them. The concern of this study is the comparison of the QOL of religious Christian to general population especially in the satification of their QOL and the structure of the QOL factors. According to the Varricchio (2006) ‘the purpose for assessing QOL must be determined to drive the measurement and interpretation approaches used in the clinical or research setting.’ Thus, this study will use the modification of WHOQOL-BREF questionnaire as the instrument, and collect 260 copies each of religious Christian and general population. The Factor Analysis, T-test and regression analysis will be employed for data analysis. The results showed Personal Belief was the second important factor of QOL. In the factor comparisons of QOL, Christians have a better QOL not only in their personal belief but also in their physical, psychological, and environmental factor. Among the 28 items, 17 items showed that significantly presented greater satisfaction level than non-Christian. In the regression analysis, Christian's QOL has positive impact from variables of physical, psychological, and personal belief. Concerning the inward and outward relationship with God, Christian's QOL is decided by the inward feeling of closeness with God but the outward spending hours involving in the church.