“Prevention is better than cure.” As the saying puts, to prevent the risk and minimize the possible damages from earthquake are one of the top priorities for museums based on the land in the seismic zones. Taking the National Museum of Taiwan History (NMTH) - one of the many museums located in the circum-Pacific belt - as example, this study discusses the probability and intensity of earthquake in the museum site in Taiwan, and how that might cause damages to the museum collections, through a series of risk assessment measures. This study also takes focused interviews of the museum staffs to analyze the current earthquake prevention measures and the reactions to the past earthquakes. The result of this research shows that the damages caused by earthquakes are from the falling and toppling over of the objects, as well as the collision between objects due to the shifting of collection cabinets. On the above account, this study proposes a warehouse design strategy for earthquake-preventive conservation in museums, covering the three aspects of storage devices, the positioning of large objects, and the packaging of small items. This proposal is expected to provide as the risk management objectives, and is examined by both the mechanic principles and the earthquake experiences in the NMTH, and has been proven as a sufficient practice of risk management in museums, as well as decreased the probability of relics damage.