As illicitly acquired inevitable stage of money laundering and the process of money laundering involving a number of different countries and regions, and international relations, criminal elements using the national legal system and political reasons favorable factors, and effectively prevent the investigation of criminal origin, thus exacerbating vicious crime syndicates. The two sides of the Strait, Hong Kong and Macau have the same culture, as well as personnel and funds have been frequent, and criminal organization are also use four different legal system and political reasons and continue their money laundering activities. This article will explore how to effectively and jointly combat money laundering.