重症病人常因疾病、免疫力低下或長期使用抗生素而產生多重抗藥性菌種。本重症加護室2014 年多重抗藥性菌種平均密度為千分之3.97，高於全院平均值(千分之0.5)，故成立專案小組，經問卷調查及實際查核，分析導因有清潔人員環境清潔方式及物品不當、醫護人員未正確執行隔離防護措施、訪客未正確執行隔離防護措施等。專案期間2015 年5 月1 日至2016 年5 月10 日，透過修訂環境清潔標準規範並提供獎勵措施、製作海報圖示、隔離防護光碟、QR code 及電視播放衛教影片等多媒體方式宣導隔離防護重要性，落實清潔人員環境清潔正確性和醫護人員及訪客正確執行隔離防護措施，有效將本重症加護室多重抗藥性菌種密度由千分之3.97 降至千分之2.75。

Critically ill patients often produce multi-drug-resistant strains due to disease, immunocompromisation, or long-term use of antibiotics. In 2014, the multi-drug-resistant strain density in our intensive care unit was reported to be 3.97 per mille, which is higher than the average hospital strain density (0.5 per mille). Questionnaires and practical checking were applied, and according to our analysis of the results, cleaning staff were using environmental cleaning methods involving inappropriate items, and medical staff and visitors were not executing correct isolation protection procedures. From May 1, 2015 to May 10, 2016, we improved the standard of the specification of environmental cleaning operations and provided rewards, in addition to creating an isolation protection health education film, cell phone QR code poster, and a television program of protective health education videos. We adopted a multimedia approach to promote the importance of isolation protection. The multi-drug-resistant strain density consequently decreased from 3.97 per mille to 2.75 per mille.