This article described nursing process of caring a patient with terminal oral cancer with pain, malodor, and appearance changes caused by malignant fungating wound. The patient also experienced anxiety because of the unpredictable disease progress and facing the fear of death. During the nursing period from 1/15/2016 to 2/23/2016, the author used Gordon's 11 Functional Health Patterns Assessment as the assessment tool, and used other methods, such as interviews and observations, to collect relevant data of the patient. The established main nursing problems were: chronic pain, impaired tissue integrity, body image disturbance, and death anxiety. During the nursing process, the author used tranquility care philosophy and established a good relationship with the patient, actively caring and listening and providing individual care and timely encouraging and accepting the expression of negative emotions. Patient-centered cares were arranged and provided by the integrated medical team. The author also provided support to patient and his family members to alleviate the physical and psychological symptoms and finally achieve the end of life care. This nursing experience provides a reference for caring similar patients.