Instructing patients to promote and maintain their own health is the most crucial job in nursing. Nursing guidance is a primary method for achieving this goal. The development of information technology allows tailored nursing instruction to be provided by establishing electronic medical databases and by using a clinical decision support information system. All patients receive enhanced professional care during hospitalization. Our research used nursing process documents of nurses in an emergency department, an intensive care unit, and a general ward at a Southern Taiwanese medical center. We used an information system to match a nursing plan with health education guidance and implemented the integrity of clinical nursing and teaching guidance. The hospital's health education guidance was categorized and used in wards that were subsequently selected. The auditing team-comprising a supervisor, a ward representative, and an N3 senior nurse-undertook monthly inspections of clinical nursing care records using the audit tables from nursing records. Finally, a total of 11,980 audit results collected over 48 months were analyzed using descriptive statistics and one-way analysis of variance to assess the integrity of nursing instruction records for hospital accreditation on the retrospective review. Our results demonstrated that, after the establishment of the nursing guidance education system in 2012, the integrity scores of nursing health education guidance records for three departments significantly improved year by year (p < .05). The integrity of clinical nursing health education records was improved with information technology. We suggest that the medical center extend education resources, such as the medical system combined with private telecom digital TV, and then provide remote health services to deliver a range of information about health.