The purpose of this study is aimed at understanding nurses' attitude toward research, their perceived support of research, their participation in research activities, and factors influencing nurses' participation in research activities. A co-relational design was used and 382 nurses were selected from a medical center. Research instruments included the attitude of nurses towards research, the nurses' perceived support of research, and the nurses' participation in research activities. Descriptive statistics, analysis of variance, and multiple regression were used for data analysis. The important findings were the following: (1) Nurses' attitude toward research was positive. (2) The most positive perceived support from the institute was that the nursing department offered continuing education for nursing research. The most negative perceived support was lack of time for conducting research. (3) Sixty-four percent of the subjects had participated in research activities in the past three years. Data gathering ranked the first priority of research activities and oral presentation at national conferences was the most common way of reporting research results. (4)The factors predicting research participation were position, educational level, number of journal subscription, statistics courses taken, and attitude toward research. Results of this study would enhance continuing education for nursing research and guide the direction of nursing research utilization in nursing practice.