The diverse forms of feelings, which are born in the experience of bodily stirrings, vary from bitterness to happiness owning to distinct situations. This variation or flowage could be described by the notion of affect. This paper, combining the relevant expositions of Spinoza with the ideas of Nietzsche, Gilles Deleuze and others, tries to explore the complicated relation between affect, body, force, desire, and life. In fact, affect, as the flow of force or puissance, shows its close relation with the force of body and underlines the existential mode of man as an affective subject, in which, there are both the criticism of Descartes’ mind-body dualism and the divergence with the Structuralists, Louis Althusser and Michel Foucault. The genealogy of affect, will to power and desire machine shows that the body and mind are never separate from each other and even though appearing in various forms, the force of life always sends out a lasting call: hold to a happy materialistic ethics.