內源性大麻素與創傷後應激障礙：可能的作用機制與治療應用_

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題名：	內源性大麻素與創傷後應激障礙：可能的作用機制與治療應用
書刊名：	心理科學進展
作者：	朱葉／曹成琦／王力
出版日期：	2017
卷期：	2017(12)
頁次：	2043-2056
主題關鍵詞：	內源性大麻素；創傷後應激障礙；恐懼記憶；焦慮；抑鬱；Endocannabinoid；Post-traumatic stress disorder；Fear memory；Anxiety；Depression
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:11

近年來,內源性大麻素系統已被視為創傷后應激障礙(PTSD)未來藥物治療的新靶標。實證研究提示,內源性大麻素系統可能通過影響個體的恐懼記憶加工、焦慮與抑郁表型以及獎勵與動機調控而參與了PTSD的發生發展。應用適量的大麻素類物質可緩解PTSD癥狀,尤其可以改善患者的睡眠問題。未來的研究應進一步明確內源性大麻素系統在PTSD病因學中的作用機制,提高現有藥用大麻素類物質的臨床安全性,并發展新型大麻素受體調節劑。另外,探討遺傳因素和反應異質性在內源性大麻素治療PTSD中的作用,也將促進治療人群的早期識別和精準醫療的發展。

以文找文

Recently, endocannabinoid system has been proposed as a new pharmacological target of post-traumatic stress disorder(PTSD). Empirical studies indicated that endocannabinoid system is closely linked to the occurrence and development of PTSD due to its important roles in regulating the fear memory, anxiety, depression, reward as well as motivation. Several clinical studies also found that appropriate dose of cannabinoids can relieve PTSD symptoms, especially the sleep problems. Future studies should further explore the pathological mechanism of endocannabinoid system in PTSD, increase the clinical security of medicinal cannabinoids,and develop the new kinds of cannabinoid receptor modulators. In addition, investigating of the influence of genetic factors and heterogeneity of responses in the effect of endocannabinoid on treatment of PTSD will also promote the early identification of the patients and the development of precision medicine.

以文找文

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圖書
1.	Substance Abuse and Mental Health Services Administration(2014)。The NSDUH report: Substance use and mental health estimates from the 2013 national survey on drug use and health: Overview of findings。Rockville, MD：Substance Abuse and Mental Health Services Administration。

圖書論文
1.	Cabral, G. A.、Ferreira, G. A.、Jamerson, M. J.(2015)。Endocannabinoids and the immune system in health and disease。Handbook of Experimental Pharmacology。Cham：Springer。
2.	de Petrocellis, L.、Bisogno, T.、Di Marzo, V.(2003)。Neuromodulatory actions of endocannabinoids in pain and sedation。Advances in Experimental Medicine and Biology。Boston, MA：Springer。

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