GABA能系統在應激誘發的抑鬱癥中的作用__臺灣人文及社會科學引文索引資料庫

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題名：	GABA能系統在應激誘發的抑鬱癥中的作用
書刊名：	心理科學進展
作者：	徐航／陳煥新／王瑋文
出版日期：	2017
卷期：	2017(12)
頁次：	2075-2081
主題關鍵詞：	應激；GABA能系統；抑鬱癥；Stress；GABAergic；Depression
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:7

γ-氨基丁酸(γ-aminobutyric acid,GABA)是中樞神經系統中最重要的抑制性神經遞質,在維持大腦的興奮-抑制平衡中起到重要作用。越來越多的臨床和基礎研究顯示抑郁癥與各種GABA能神經元活動不足相關,抗抑郁藥物可以緩解或恢復上述變化。GABA能系統延遲發育至成年早期基本成熟。應激,尤其是早期應激是抑郁癥發病的重要風險因素,可以通過擾動GABA能系統的發育軌跡從而造成對該系統結構和功能的持續后果,并與后期抑郁癥易感密切相關。未來的研究需要進一步鑒別二者之間的關系,進而提出以GABA能系統為靶標的抑郁癥治療新策略。

以文找文

γ-aminobutyric acid(GABA) is the most important inhibitory amino acid neurotransmitter in the central nervous system to maintain the excitatory-inhibitory balance of the brain. Increasing clinical and pre-clinical evidence shows a central and causal role of GABAergic deficits in depressive disorders. Depressive patients commonly indicate reduced GABAergic transmission in emotional and cognitive brain areas, especially prefrontal cortex and limbic areas like hippocampus and amygdala, and antidepressants can alleviate or reverse depressive symptoms by augmenting GABAergic activity in these areas. Furthermore, deficits in GABAergic transmission are sufficient to cause most of the neural and behavioral alterations expected in an animal model of depression. GABAergic system undergoes a prolonged development to structural and functional maturation until into early adulthood in both human and rodents. Stress, especially early stress, may disturb the mature trajectory of the GABAergic system, and result in continuing negative consequences of neural development and late functioning, which can contribute to the increased susceptibility for the onset of depression across late life. It would be important to further elucidate GABAergic mechanisms underlying depressive disorders and action of antidepressant in order to improve strategy for early recognition and intervention of depression.

以文找文

期刊論文
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學位論文
1.	Hu, W.(2010)。Effects of stress on the GABAergic system in the hippocampal formation and medial prefrontal cortex of the adult male rat(博士論文)。Georg-AugustUniversität Göttingen。

圖書
1.	鞠躬(2004)。神經生物學。北京：人民衛生出版社。延伸查詢

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