Chemical industry is one of elementary industries in Taiwan and its has extremely correlation with other industries; it plays not only dominated role in our daily life but also the source provider of High-Tech industries, so it is very important in gross economic growing. Recently, accompanying with the technology development, chemical substances are widely used. The amount of chemical substances in operation grows rapidly, so the potential risk is increasing. Once a HAZMAT disaster happens, the first responder’s size-up and response in the beginning of the disaster would determine if they can control the scene and reduce the damage or cause a serious problem. The object of this research is to facilitate modern information technologies such as, Geographic Information System, GIS Through the IT’s, large amount of complex spatial; and attribute data can be manipulated. Information technologies can be auxiliaries for decision support and command system. The contents of this research take the information of those domestic factories which manufacture and use serious hazardous substances as the frame, and combine HAZMAT, emergency medical services, and the establishment of prevention map to provide correct and professional knowledge to the first responders at the first time; help them to take appropriate emergency response actions effectively and strengthen the emergency response, management of consultation and communication for chemical hazard response, management of toxic substance rescuing, inquiry of industry are and chemical hazard sensitive area, emergency medical service, and hazard rescuing to establish the foundation of modern fire administration and chemical hazard rescuing.