When death is imminent, should Christian choose active euthanasia—withholding or withdrawing life support systems? Is there a Christian perspective on these issues which pastors can provide to those in such situations? In 1973 the House of Delegates of the American Medical Association (AMA) declared their opposition to mercy-killing. Yet in contrast, James Rachels insisted that there is no significant distinction between mercy-killing (or active euthanasia) and the withdrawal of life support system (or passive euthanasia), a practice which the AMA supports. This article seeks to point out such a difference between active and passive euthanasia. From its earliest days, the Christian faith has taught that in Jesus there is a resurrection of the dead. In 1 Corinthian 15:26, death is the final enemy and it is destroyed. For Paul, death and resurrection represent a personal mystical experience, which leads him to proclaim his participation in Jesus’ crucifixion, death, and resurrection. Therefore he can say, “it is no longer I who live, but it is Christ who lives in me” (Gal. 2:20). Through his spiritual journey, Paul surpasses the anxiety of dying and death. In its conclusion, this article suggests that Paul’s spiritual journey sheds light on end-of-life issues. Pastors, as spiritual guides, have the responsibility to explicate the moral significance of this message.