Objective: The purpose of this study was to explore relationships among parental bonding, family function and depression in adolescent populations through a one-year follow-up study. Risk factors and possible explanations for adolescent depression were also investigated. Method: The subjects of this study were 1028 junior high school students in a city of the Southern Taiwan. The parental attitudes and behaviors, family function, and depression disposition currently perceived by the adolescents were evaluated using the Parental Bonding Instrument (PBI), the Family Function Scale-child edition (FFS)and the Children Depression Inventory (CD). Result: The results revealed that (1) Demographic variables of gender and family type was significantly different for adolescents' depression dispositions; depression index in girls was significantly higher than in boys during the one year interval and depression index in the single-parent family was significantly higher than in the other family type. (2) Regression analysis found that female, single-parent family, high family conflict, high mother caring, low family responsibility and high family involvement were the most significant variables to predict the depression disposition in adolescents. (3) Low family function and the depression disposition previously given had the important impact to affect the depression states in adolescents. Conclusion: It is important to conduct the family therapy for the adolescents' depression than through the individual therapy.