According to the report of IC insights, which reported that Taiwan ranked no.1 in the world, as the most important country of semi-conductor industry production in 2011. IC insights is a company that leading semi-conductor market research. It was the first time that Taiwan had overtaken Japan and South Korea. In the same year, China also ranked in the top 5 in the world first time. In addition to the world's large and expanding semi-conductor market, the manufacturing technology and human resources of Taiwanese companies have contributed to China's rise in semi-conductor industry. Semiconductor companies in Taiwan might still consider moving to China because of lower cost production conditions and the cluster effect in China though Taiwan's semi-conductor industrial supplied-chain is well-established and its manufacturing capability is excellent. This paper intends to find out the factors affecting the development of semi-conductor industry in Taiwan and China. The Factor Endowment Theory and Wage Theory were applied to analyze the situation in this paper. This paper also conducted interviews with corporate staff. In addition, a grey prediction model was created to estimate the output value of semi-conductors for Taiwan and China in 2013 and 2014. The estimation shows that the production rate of semi-conductor industry is on the rise in China and on the decline in Taiwan. This paper suggests Taiwanese companies should access existing manufacturing advantages to upgrade their equipment and human resources. A high level of investment on the part of the Taiwanese government is also required to help semi-conductor companies in Taiwan soar to a new height.