Since the liberalization of gambling sector and the Individual Visit Scheme in Macau, Macau’s economy outperforms most Asian countries. However, Macau also faces many new challenges, like illegal hostels, cross border crime, food safety issues and the milk powder shortage issue. All these new challenges always catch public’s attention. It is necessary for the Government to set up or upgrade her emergency response mechanism. As the milk powder shortage issue occurs simultaneously in Hong Kong and Macau, so the study aims at comparing the handling methods of two governments through crisis management theory. Therefore, the study delivers literature reviews on crisis management briefly, discusses the similarities and differences between the handling methods of the two governments, as well as, proposes some recommendations.