The purpose of this study was to explore the concered themes and communication patterns of chronic schizophrenic patients and their spouses in the process of couple therapy. The research used the quilitative research design. Eight couples were tape recorded for one hour discussion across three months during the therapy. Data were transcribed into narratives and systematically analyzed and categoried. Results showed that the concerned themes during the therapy process could be categoried as illness information processing, intrapersonal identity processing, and inter-personal interaction processing. Communication patterns expressed by the couples under each theme could be viewed as facilitating or hindering communication; empathetic, expressive, suppressive, and rejected were categoried. Study findings highlighted the major foci during couple therapy of schizophrenic patients and their spouses were on the illness information. Couple therapy could improve communication pattern and facilitate change. The significance of the result demonstrated that nurse could take active roles in couple therapy.