基因與環境的交互作用：來自差別易感性模型的證據__臺灣人文及社會科學引文索引資料庫

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題名：	基因與環境的交互作用：來自差別易感性模型的證據
書刊名：	心理科學進展
作者：	趙德懋／馮姝慧／邢淑芬
出版日期：	2017
卷期：	2017(8)
頁次：	1310-1320
主題關鍵詞：	基因-環境交互作用；基因；差別易感性；優勢敏感性；Gene-environment interaction；Gene；Differential susceptibility；Vantage sensitivity
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:3 點閱:9

差別易感性模型認為,攜帶某種基因型的個體既容易受到消極環境的不利影響,同時也容易受到積極的、支持性環境的有利影響。隨著定量遺傳學和分子遺傳學技術的不斷發展,涌現出關于基因-環境對兒童發展交互作用的大量研究,主要包括5-HTTLPR、DRD4、MAOA、COMT和BDNF五種基因與環境因素(如,母親敏感性、壓力性生活事件和家庭養育環境等)對兒童發展的交互作用,支持了差別易感性模型。但是,關于基因與環境交互作用的機制、攜帶易感性基因個體的種族和性別差異問題以及優勢敏感性假說的驗證,都是該領域未來研究的重要方向。

以文找文

According to the differential susceptibility model, individuals with certain genetypes are not only more vulnerable than others to the negative effects of adversity, but also disproportionately susceptible to the beneficial effects of supportive and enriching rearing environment. With the advancement of quantitative genetics and molecular genetics, a great many researches on the effect of gene-environment interaction on children’s development have emerged in recent years. For example, researches have been done regarding the interaction between environment（such as maternal sensitivity, stressful life events and family upbringing） and five candidate genes — 5-HTTLPR, DRD4, MAOA, COMT and BDNF — all of which support the differential susceptibility model. The underlying mechanisms of gene-environment interaction, racial and gender differences between individuals carrying vulnerable genes as well as further estimation of vantage sensitivity hypothesis are all important directions of future researches in this area.

以文找文

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