【Purpose/significance】There are many loopholes in China’s existing system on protecting personal informationfully and effectively. Therefore, both theoretically and practically, it is necessary to learn from the information system of ad-vanced countries or regions.【Method/process】This article mainly uses the model comparison to analyze the similarities anddifferences of personal information protection in U.S. and E.U., in order to explore the concept and principles of protectingpersonal information.【Result/conclusion】In essence, there are some aspects in common about the privacy protection in U.S., the self-determination right of personal information in E.U., and the protection of personality under the constitution ofour country. Compared with unified legislation or decentralized legislation, China should establish personal information pro-tection system based on its own national conditions, the international standards, and the legislative practice of major nationsin the world.