干預膽堿M受體對藥物成癮的影響及其與多巴胺的關係__臺灣人文及社會科學引文索引資料庫

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題名：	干預膽堿M受體對藥物成癮的影響及其與多巴胺的關係
書刊名：	心理科學進展
作者：	劉昕鶴／田琳／劉佳琳／李新旺
作者(外文)：	Liu, Xinhe／Tian, Lin／Liu, Jialin／Li, Xinwangp
出版日期：	2016
卷期：	2016(8)
頁次：	1217-1227
主題關鍵詞：	藥物成癮；M受體；多巴胺；膽堿能系統；Drug addiction；Muscarinic receptor；Dopamine；Cholinergic system
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:157

藥物成癮是一類精神及行為障礙,涉及到中樞神經系統的病變。毒蕈堿受體(Muscarinic receptor,M受體)屬於膽堿能受體,分5種亞型。行為學研究表明,干預M受體能有效影響藥物成癮行為,但其神經機制還亟待探索。阿片類藥物與精神活性藥物均能激活中樞多巴胺系統,而M受體與多巴胺系統在多個腦區產生了交互作用。其中激動M2及M4受體抑制了多巴胺系統功能,而激動M5受體增強了多巴胺系統功能,與干預M2、M4、M5受體對藥物成癮行為的影響相對應。以上證據提示,干預M受體可能通過影響多巴胺系統對藥物成癮起作用。

以文找文

Drug addiction is a disease with central nervous system dysfunction. Muscarinic receptor belong to cholinergic system, has five subtypes, M1-M5 receptors. Behavioral research show that interference with M receptor could affect drug addiction behavior. Both opioids and psychoactive drugs could active central DA system. And M receptor regulating dopamine system in various brain areas, implicate there is a potential way that M receptor affect addiction behavior through interaction with DA system. Activing M2 and M4 receptor could inhibit DA system activating, and active M5 receptor could facilitate DA system activating, in corresponding to the effect of intervened with M2、M4、M5 receptor in drug addiction behavioral research. These evidences prove that M receptor regulating DA system in drug addiction behavior, and M receptor could be new neural target for treatment of drug addiction.

以文找文

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