Objectives: Medical research, reimbursement system and classification of DRGs depend on the accuracy and completeness of disease coding. A research showed that the error rate of overall disease coding was 52% in Taiwan,and for which qualification and manpower of coding personnel are important factors. The purpose of this study was to assess college graduates' willingness to work as disease coding personnel and the influencing factors. The contents of the questionnaire included arrangement of curriculum, te aching methods and attitudes, learning atmosphere of classmates, self-sensed importance of curriculum, interests, and working willingness. Methods: Samples are collected by a stratified-cluster method. Eight hundred and twenty-one questionnaires were distributed and 780 effective cases were returned. Results: The outcome of the instructor's influence and self-sensed importance of curriculum were positive; the attitude toward the arrangement of curriculum,interests and working willingness were negative. Cha racteristic factors which influence on working willingness found that females, aged over 31, students in night schools contribute to a higher working willingness. Factors which influence on working willingness are interest toward curriculum(major) and self-sensed importance of curriculum(minor). Conclusions and suggestions: Sex,age,academic program, interest to curriculum, and self-sensed importance of curriculum are the relative factors toward working willingness.We suggested to enhance English ability an d professional medical knowledge for coding improvement. A quiz before the national examination is important for increasing the confidence and motivation of the student.