This article describes the nursing process of a twenty-four-year-old female patient who faced trauma, impaired physical function and psychical impact after receiving multiple debridement, free-flap operation and above-knee amputation. The nursing experience happened between May 30 and July 20 in 2007. Both subjective and objective data were collected through communication, interviews and chart reviews. The issues addressed included physical, psychological, social and spiritual aspects of the patient. The identified problems of the patient were acute pain, impaired physical mobility, disturbed body image, post-trauma response and anxiety. During the nursing process, the patient’s pain and impaired physical mobility were both relieved by listening, caring and showing empathy from the author. Support and encouragement were also offered to the patient to face the reality of a change of her body, and to receive attended rehabilitation project for recovery. This nursing experience of holistic care can be valuable to other healthcare professionals. It is expected that the nursing staff would be able to develop adequate nursing intervention skills to help relieving the amputated patients’ physical discomfort, but also to attend the psychological needs of the patients.