In recent years, coffee drinking population keeps growing and has become a consumer market with great potential. By various baking and manufacturing processes, the coffee beans produce different types of tastes, and then consumers can choose according to their own favor. During the baking process, the coffee beans produce Maillard reaction to give bitter taste and sour substances. Among these substances, caffeine is a stimulant with a bitter taste and caffeic acid is a kind of phenolic compounds with the antioxidant, anti-virus and liver protecting functions. For meeting the demands of modern life on healthy diets, this study focused on the introduction of coffee main compositions and discussed the effects of caffeine and caffeic acid to antitumor and anti-inflammatory by a systematical analysis. The results may provide clearer understanding of the coffee and strengthen the concepts of food safety and health diets.