The main purpose of this study was to investigate the effectiveness of metacognitive strategies instruction on the performance of reading comprehension of this study were as follows: (1)Regular classroom students had a significantly higher score than students with reading disabilities on the performance of Metacognition Reading Measurement and Reading Motivational Beliefs Scale. (2)After receiving metacognitive strategies instruction, the experimental group of students with reading disabilities made significant gains than the control group of students with reading disabilities on the Metacognition Reading Measurement and Reading Comprehension Test in each evaluational phase immediately, two weeks, and twelve weeks after the strategies instruction. (3)Though the metaognitive strategies training program integrated the instruction of motivational beliefs, there were no significant differences between the experimental and control groups of on the Reading Motivation Belief scale in all three evaluational phases. (4)The metacognition was the main variable to explain the reading comprehension performance of the experimental group of students with reading disabilities.