The purpose of this study was t oexplore job stressors and related factors among 80 home healthcare nurses. Stressors were classified into six categories: patient care, family, nursing knowledge, nursing skills, nursing attitude and working situation. The results revealed that the most stressful category was patient care followed by working situation, family, nursing knowledge, nursing skills and nursing attitude. The results also found that (1) Single nurses and nurses without children experienced singificant stress in nursing knowledge and nursing skills. Age had significantly different effects on stressors in family, nursing knowledge, nursing skills and working situation. (2) The level of nursing education did not have a significantly different effect on stressors in the six categories. However,those who did not have home healthcare training experienced significant stress in nursing skills, while those who had training experienced significant stress in nursing attitude. (3) The experience in home health care or clinical care did not have a significantly different effect on stressors in all six categories. Those who had experience in teaching or public health nursing showed lower stress in patient care, nursing knowledge and nursing attitude. The study proposed three recommendations to reduce job stressors among home healthcare nurses.