In this study, a cross-sectional survey with case control by using HOME Inventory (the Inventory of Home Observation for Measurement of the Environment) , Standford Binet Intelligent test, and WISC-Rtest (Wechsler Intelligent Scale for Children, Revised Version) to detect the cognitive development of PCBs (Polychlorinated Biphenyls) children, and the effects of home environmental factors on cognitive development were carried out. The relationship between home environmental factors and intelligent quotient were also studied. The reserch samples consisted of 116 pairs (232 children), and 7 factors in biology and social environmental factors, such as with or without poisoning by PCBs, age, sex, SES and so on were matched. In this research the main points are summerized as follows:1. In many sub-scales of IQ tests (SB and WISC-R), the IQ scores of PCBs group were below those of the control group, and the differences reached statistical significant levels.2. The maean valuse of HOME score of the PCBs group were below of the control group in many sub-scales, and the values in many sub-scale reached statistical significant levels.3. Using analysis of covariance and stepwise regression analysis, It was discovered that the IQ values of PCBs Group were not different from those of the control group, and it seems evident that the home environmental factors were the major causes of lower IQ in PCBs children.4. The IQ values of the PCBs and the control children groups were lower than the normal values in the Taiwan area.Although the research results revealed that both of the IQ and HOME scores in PCBs group were all below those in the control group, and that the major factors affect the cognitive developments seems to be home environment, There are still some limitations in the study. Therefore, which is the cause or the result can not be judged from this study. It still needs some further efforts provides a storng argument for intervention by public health professionals to help the low HOME score families.