This study was designed to investigate sexual harassment by patients and nurses' responses in dealing with sexual harassment. The study was conducted in a medical center. A total of 251 nurses, working at evening/night shifts in the general wards, were asked to fill out a semi-structured questionnaire. The nurses were asked to describe the latest incidence and their responses of the sexual harassment by patients in the previous two years. The results showed that 115 (45.8%) nurses were sexually harassed by patients in the previous two years. From an analysis of 78 incidents, sexual harassment included verbal forms (15.4%), physical touching (38.5%), non-verbal forms (25.6%), and telephone harassment (20.5%). Nurses responses included assertive and passive styles. For physical touching, most victims reactecl assertively. As for non-verbal forms of sexaul harassment, most victims responded passively. Regarding all forms of sexual harassment, the victims were hurt psychologically, job performance was affected, and nursing quality was impacted. The study showed that sexual harassment exists in the medical practice and the nurses' ability to deal with the sexual harassment is limited. This study suggests that nurses and nursing administrator should pay much attention to sexual harassment by patients, provide assertiveness training, and build up an incident reporting system.