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題名：多囊性卵巢症候群相關因子與性傾向相關性之探討
作者：陳菁徽
作者(外文)：Ching-Hui Chen
校院名稱：樹德科技大學
系所名稱：人類性學研究所
指導教授：朱元祥
學位類別：博士
出版日期：2014
主題關鍵詞：異性戀；同性戀；多囊性卵巢症候群；性傾向；台灣；heterosexual；lesbian；polycystic ovary syndrome；sexual orientation；Taiwan.
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多囊性卵巢症候群是一項常見的婦科疾病，常導致諸多荷爾蒙失調的症狀，尤其其引起之不孕症，影響了4-10%生育年齡的婦女。此症候群臨床上常呈現雄性激素血中濃度增高，排卵能力降低，寡經，身體和面部毛髮增生，青春痘，以及多囊性卵巢的情況。此外，也可能造成代謝性的荷爾蒙失調，與胰島素阻抗症。多囊性卵巢症候群之致病機轉至今仍未清楚，但觀察到此症候群常與不孕症，第二型糖尿病，心血管疾病，以及子宮內膜癌的發生有關。此外，也有一些研究表明，多囊性卵巢症候群的發生率可能因種族以及性傾向而不同。然而，此症候群的患病率與特定性傾向族群之關係，目前仍付之闕如。因此，在本研究中，我們嘗試探索性傾向以及多囊性卵巢症候群在臨床上相關之危險因子的關聯。
在本研究中，我們採取橫斷面研究方法，自台北醫學大學婦產科門診病患中招募受試者。總共有177例受試者參與了本研究。我們發現，在多囊性卵巢症候群的患者中，相較異性戀婦女族群，性傾向為女同性戀者顯著具有較高的身體質量指數(BMI= 22.5±5.2 v.s. 26.2±1.9; p=0.031)，並且有較高的家族糖尿病史比例 (85.7% v.s. 64.4%)。這暗示了女同性戀族群可能是多囊性卵巢症候群相關的糖尿病之高危險性族群。
本研究探討多囊性卵巢症候群之相關因子與性傾向之關聯性，有助於了解多囊性卵巢症候群是否於女同性戀族群中有更高的發生率，以及其可能的原因。本研究成果將有助於臨床上針對女同性戀的多囊性卵巢症候群患者進行更有效的疾病預防與治療。
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder, affecting 4-10% of reproductive-aged women worldwide. The clinical diagnostic criteria for PCOS include androgen excess (either clinical or biochemical), anovulation, and polycystic ovaries (PCO) as observed by ultrasound. Hence, the clinical signs and symptoms of PCOS are related to hormonal imbalances, lack of ovulation and insulin resistance, leading to consequences of: irregular or absent menstrual periods, excessive growth of body and facial hair, adult acne, PCO, metabolic syndrome, and endometrial cancer. The exact cause of PCOS is unclear; it is considered a complex genetic disease that is often associated with infertility, type II diabetes, cardiovascular disease, and endometrial cancer. There are a few studies that have indicated that the prevalence and features of PCOS may vary by race and sexual orientation. However, studies on the connection between the prevalence of polycystic ovary syndrome and sexual orientation have been the subject of relatively little health research. In this study, we aim to explore the association between sexual orientation and PCOS-related parameters.
A cross-sectional study method with participants recruited from the regular outpatient clinic at the department of Obstetrics and Gynecology at Taipei Medical University Hospital was carried out. A total of 177 patients participated in the study. We found that patients with PCOS who identified themselves as lesbians (with regard to sexual orientation) tended to possess higher body mass index (26.2±1.9 v.s. 22.5±5.2; p=0.031) and higher rate of DM family background (85.7% v.s. 64.4%) than the women in the study with PCOS that identified themselves as heterosexuals. Our data indicated that high BMI was associated with sexual orientation (as evidenced by the results of lesbian PCO women in Taiwan), and may cause women who identify themselves as lesbians to be more vulnerable to PCOS-related DM. As health risks related to hormonal imbalances may be underestimated in the homosexual population due to cultural factors, the results could help to identify a potential high risk population to PCOS, and contribute to women’s health care in the future.
1.Agrawal, R., Sharma, S., Bekir, J., Conway, G., Bailey, J., Balen, A. H., & Prelevic, G. (2004). Prevalence of polycystic ovaries and polycystic ovary syndrome in lesbian women compared with heterosexual women. Fertil Steril, 82(5), 1352-1357. doi: 10.1016/j.fertnstert.2004.04.041
2.Ayala, C., Steinberger, E., Smith, K. D., Rodriguez-Rigau, L. J., & Petak, S. M. (1999). Serum testosterone levels and reference ranges in reproductive-age women. Endocr Pract, 5(6), 322-329. doi: 10.4158/EP.5.6.322
3.Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., . . . Androgen Excess, S. (2006). Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab, 91(11), 4237-4245. doi: 10.1210/jc.2006-0178
4.Azziz, R., Marin, C., Hoq, L., Badamgarav, E., & Song, P. (2005). Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J Clin Endocrinol Metab, 90(8), 4650-4658. doi: 10.1210/jc.2005-0628
5.Balen, A. H., Laven, J. S., Tan, S. L., & Dewailly, D. (2003). Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update, 9(6), 505-514.
6.Barber, T. M., McCarthy, M. I., Wass, J. A., & Franks, S. (2006). Obesity and polycystic ovary syndrome. Clin Endocrinol (Oxf), 65(2), 137-145. doi: 10.1111/j.1365-2265.2006.02587.x
7.Barefoot, J. C., Brummett, B. H., Clapp-Channing, N. E., Siegler, I. C., Vitaliano, P. P., Williams, R. B., & Mark, D. B. (2000). Moderators of the effect of social support on depressive symptoms in cardiac patients. Am J Cardiol, 86(4), 438-442.
8.Boehmer, U., & Bowen, D. J. (2009). Examining factors linked to overweight and obesity in women of different sexual orientations. Prev Med, 48(4), 357-361. doi: 10.1016/j.ypmed.2009.02.003
9.Broekmans, F. J., Knauff, E. A., Valkenburg, O., Laven, J. S., Eijkemans, M. J., & Fauser, B. C. (2006). PCOS according to the Rotterdam consensus criteria: Change in prevalence among WHO-II anovulation and association with metabolic factors. BJOG, 113(10), 1210-1217. doi: 10.1111/j.1471-0528.2006.01008.x
10.Carmina, E., Koyama, T., Chang, L., Stanczyk, F. Z., & Lobo, R. A. (1992). Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome? Am J Obstet Gynecol, 167(6), 1807-1812.
11.Chen, X., Yang, D., Li, L., Feng, S., & Wang, L. (2006). Abnormal glucose tolerance in Chinese women with polycystic ovary syndrome. Hum Reprod, 21(8), 2027-2032. doi: 10.1093/humrep/del142
12.De Sutter, P., Dutre, T., Vanden Meerschaut, F., Stuyver, I., Van Maele, G., & Dhont, M. (2008). PCOS in lesbian and heterosexual women treated with artificial donor insemination. Reprod Biomed Online, 17(3), 398-402.
13.DeVane, G. W., Czekala, N. M., Judd, H. L., & Yen, S. S. (1975). Circulating gonadotropins, estrogens, and androgens in polycystic ovarian disease. Am J Obstet Gynecol, 121(4), 496-500.
14.Dunaif, A. (1997). Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev, 18(6), 774-800. doi: 10.1210/edrv.18.6.0318
15.Ehrmann, D. A., Liljenquist, D. R., Kasza, K., Azziz, R., Legro, R. S., Ghazzi, M. N., & Group, P. C. T. S. (2006). Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab, 91(1), 48-53. doi: 10.1210/jc.2005-1329
16.Esposito, K., Ciotola, M., Giugliano, F., Bisogni, C., Schisano, B., Autorino, R., . . . Giugliano, D. (2007). Association of body weight with sexual function in women. International Journal of Impotence Research, 19(4), 353-357. doi: DOI 10.1038/sj.ijir.3901548
17.Ferraresi, S. R., Lara, L. A., Reis, R. M., & Rosa e Silva, A. C. (2013). Changes in sexual function among women with polycystic ovary syndrome: a pilot study. J Sex Med, 10(2), 467-473. doi: 10.1111/jsm.12011
18.Ferriman, D., & Gallwey, J. D. (1961). Clinical assessment of body hair growth in women. J Clin Endocrinol Metab, 21, 1440-1447. doi: 10.1210/jcem-21-11-1440
19.Fredriksen-Goldsen, K. I., Kim, H.-J., Barkan, S. E., Muraco, A., & Hoy-Ellis, C. P. (2013). Health Disparities Among Lesbian, Gay, and Bisexual Older Adults: Results From a Population-Based Study. American Journal of Public Health, 103(10), 1802-1809. doi: 10.2105/AJPH.2012.301110
20.Gartrell, N. K., Loriaux, D. L., & Chase, T. N. (1977). Plasma testosterone in homosexual and heterosexual women. Am J Psychiatry, 134(10), 1117-1118.
21.Hsu, M. I. (2013). Changes in the PCOS phenotype with age. Steroids, 78(8), 761-766. doi: 10.1016/j.steroids.2013.04.005
22.Hurd, W. W., Abdel-Rahman, M. Y., Ismail, S. A., Abdellah, M. A., Schmotzer, C. L., & Sood, A. (2011). Comparison of diabetes mellitus and insulin resistance screening methods for women with polycystic ovary syndrome. Fertil Steril, 96(4), 1043-1047. doi: 10.1016/j.fertnstert.2011.07.002
23.Ibricevic, D., & Asimi, Z. V. (2013). Frequency of prediabetes in women with polycystic ovary syndrome. Med Arh, 67(4), 282-285.
24.Kulshreshtha, B., Singh, S., & Arora, A. (2013). Family background of Diabetes Mellitus, obesity and hypertension affects the phenotype and first symptom of patients with PCOS. Gynecol Endocrinol, 29(12), 1040-1044. doi: 10.3109/09513590.2013.829446
25.Kumar, A., Woods, K. S., Bartolucci, A. A., & Azziz, R. (2005). Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf), 62(6), 644-649. doi: 10.1111/j.1365-2265.2005.02256.x
26.Lauritsen, M. P., Bentzen, J. G., Pinborg, A., Loft, A., Forman, J. L., Thuesen, L. L., . . . Nyboe Andersen, A. (2014). The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-Mullerian hormone. Hum Reprod, 29(4), 791-801. doi: 10.1093/humrep/det469
27.Liang, S. J., Hsu, C. S., Tzeng, C. R., Chen, C. H., & Hsu, M. I. (2011). Clinical and biochemical presentation of polycystic ovary syndrome in women between the ages of 20 and 40. Hum Reprod, 26(12), 3443-3449. doi: 10.1093/humrep/der302
28.Liou, T. H., Yang, J. H., Hsieh, C. H., Lee, C. Y., Hsu, C. S., & Hsu, M. I. (2009). Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women. Fertil Steril, 92(6), 1960-1965. doi: 10.1016/j.fertnstert.2008.09.003
29.Lord, J. M., Flight, I. H., & Norman, R. J. (2003). Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ, 327(7421), 951-953. doi: 10.1136/bmj.327.7421.951
30.Mansson, M., Norstrom, K., Holte, J., Landin-Wilhelmsen, K., Dahlgren, E., & Landen, M. (2011). Sexuality and psychological wellbeing in women with polycystic ovary syndrome compared with healthy controls. Eur J Obstet Gynecol Reprod Biol, 155(2), 161-165. doi: 10.1016/j.ejogrb.2010.12.012
31.Miller, K. K., Rosner, W., Lee, H., Hier, J., Sesmilo, G., Schoenfeld, D., . . . Klibanski, A. (2004). Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods. J Clin Endocrinol Metab, 89(2), 525-533. doi: 10.1210/jc.2003-030680
32.Moghetti, P., Castello, R., Negri, C., Tosi, F., Perrone, F., Caputo, M., . . . Muggeo, M. (2000). Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab, 85(1), 139-146. doi: 10.1210/jcem.85.1.6293
33.Monga, M., Alexandrescu, B., Katz, S. E., Stein, M., & Ganiats, T. (2004). Impact of infertility on quality of life, marital adjustment, and sexual function. Urology, 63(1), 126-130.
34.Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007). Polycystic ovary syndrome. Lancet, 370(9588), 685-697. doi: 10.1016/S0140-6736(07)61345-2
35.Norman, R. J., Masters, S., & Hague, W. (1996). Hyperinsulinemia is common in family members of women with polycystic ovary syndrome. Fertil Steril, 66(6), 942-947.
36.Pigny, P., Jonard, S., Robert, Y., & Dewailly, D. (2006). Serum anti-Mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome. J Clin Endocrinol Metab, 91(3), 941-945. doi: 10.1210/jc.2005-2076
37.Rellini, A. H., Stratton, N., Tonani, S., Santamaria, V., Brambilla, E., & Nappi, R. E. (2013). Differences in sexual desire between women with clinical versus biochemical signs of hyperandrogenism in polycystic ovarian syndrome. Horm Behav, 63(1), 65-71. doi: 10.1016/j.yhbeh.2012.10.013
38.Rotterdam, E. A.-S. P. C. W. G. (2004). Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril, 81(1), 19-25.
39.Salley, K. E., Wickham, E. P., Cheang, K. I., Essah, P. A., Karjane, N. W., & Nestler, J. E. (2007). Glucose intolerance in polycystic ovary syndrome--a position statement of the Androgen Excess Society. J Clin Endocrinol Metab, 92(12), 4546-4556. doi: 10.1210/jc.2007-1549
40.Smith, H. A., Markovic, N., Matthews, A. K., Danielson, M. E., Kalro, B. N., Youk, A. O., & Talbott, E. O. (2011). A comparison of polycystic ovary syndrome and related factors between lesbian and heterosexual women. Womens Health Issues, 21(3), 191-198. doi: 10.1016/j.whi.2010.11.001
41.Somani, N., & Turvy, D. (2014). Hirsutism: an evidence-based treatment update. Am J Clin Dermatol, 15(3), 247-266. doi: 10.1007/s40257-014-0078-4
42.Stovall, D. W., Scriver, J. L., Clayton, A. H., Williams, C. D., & Pastore, L. M. (2012). Sexual function in women with polycystic ovary syndrome. J Sex Med, 9(1), 224-230. doi: 10.1111/j.1743-6109.2011.02539.x
43.Vrbikova, J., Grimmichova, T., Dvorakova, K., Hill, M., Stanicka, S., & Vondra, K. (2008). Family history of diabetes mellitus determines insulin sensitivity and beta cell function in polycystic ovary syndrome. Physiol Res, 57(4), 547-553.
44.Wild, R. A., Carmina, E., Diamanti-Kandarakis, E., Dokras, A., Escobar-Morreale, H. F., Futterweit, W., . . . Dumesic, D. A. (2010). Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society. J Clin Endocrinol Metab, 95(5), 2038-2049. doi: 10.1210/jc.2009-2724
45.Zegers-Hochschild, F., Adamson, G. D., de Mouzon, J., Ishihara, O., Mansour, R., Nygren, K., . . . World Health, O. (2009). The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) Revised Glossary on ART Terminology, 2009. Hum Reprod, 24(11), 2683-2687. doi: 10.1093/humrep/dep343


 
 
 
 
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