The main purpose of this paper was to examine any effect of a cognitive-behavior relapse prevention program on cognitive and attitude change among sex offenders in the Taipei prison. This research used pretest-posttest design. Following the signing of informed consent forms, 88 offenders were recruited (48 as the experimental group and 40 as the control group). The experimental group received 16 weeks of group psychotherapy directed by psychologists and the control group did not receive any program input related to psychotherapy during this period of time. Results using analysis of variance with repeated measures indicated that scores of empathy for victims were significantly different between experimental and control groups. The results also showed that there was an interaction effect of experimental intervention and time on the denial of crimes. Specifically, contrary to the control group, the intervention may have positive effects on empathy for victims and denial of crimes. The findings of this paper supported evidence for the effectiveness of group psychotherapy and can be taken into consideration when making relevant policies and designing appropriate content for prevention programs.