The anonymous book of the Chu Bamboo Slips was a manuscript produced before 300 B.C. In view of the editing formats and the questions and topics presented here, we can infer that this is an early philosophical text of Confucianism. Most scholars agree on the fact that the anonymous book was written by Confucius and the seventy disciples of his. The “doctrine of mind and human nature” is central to Confucianism, and this doctrine was more widely and profoundly developed in Neo-Confucianism due to the influence of Buddhism and Taoism. The distinction between Zhu Xi and the Lu-Wang school is their difference in the doctrine of mind and human nature. The Lu-Wang school claimed that Mind is Li (reason), while Zhu Xi maintained that Nature is Li (reason). This paper is meant to compare the similarity and difference between Zhu Xi's doctrine and the “doctrine of nature” recorded in the anonymous book of the Chu Bamboo Slips so as to stress the strengths, sophistication and wholeness of Zhu Xi's doctrine of human nature.