癌因性疲憊相關之病理生理機轉__臺灣人文及社會科學引文索引資料庫

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題名：	癌因性疲憊相關之病理生理機轉
書刊名：	安寧療護
作者：	趙基安／許名雅／陳虹汶／蘇文浩／黃麗卿／鄒孟婷
作者(外文)：	Chao, Chi-an／Hsu, Ming-ya／Chen, Hong-wen／Su, We-hao／Hwang, Lee-ching／Tsou, Meng-ting
出版日期：	2011
卷期：	16:3
頁次：	頁348-360
主題關鍵詞：	癌因性疲憊；機轉；病理生理學；癌症；Cancer-related fatigue；Mechanism；Pathophysiology；Cancer
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(3) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:3 共同引用:0 點閱:66

癌因性疲憊是癌症病人所經驗到最常見且複雜的症狀之一，不僅讓病人非常困擾，對生活品質亦造成極大的影響。本篇論文針對癌因性疲憊的機轉及病理生理學，進行廣泛的文獻回顧，目前被提出的機轉包括：促發炎性細胞激素失調、下視丘-腦垂體-腎上腺軸功能障礙、血清素失調、晝夜節律失調、貧血、三磷酸腺苷代謝異常、迷走神經傳入活化、生長因子假說及基因的影響。透過機轉的進一步釐清，當有利於臨床醫師在癌因性疲憊的診斷、預防及處置方面有更進一步的研究。

以文找文

Cancer-related fatigue (CRF) is one of the most common and complex symptoms experienced by patients with cancer. It is one of the most distressing symptoms and can diminish quality of life profoundly. This article mainly focuses on the current hypothetic mechanisms and pathophysiology of cancer-related fatigue. The proposed mechanisms include proinflammatory cytokine hypothesis, hypothalamic-pituitary-adrenal-axis dysfunction, serotonin dysregulation, circadian rhythm modulation hypothesis, anemia, adenosine triphosphate hypothesis, vagal-afferent-activation hypothesis, growth factor hypothesis and genes. These mechanisms provide a basis for future research of CRF and provide new routes for clinicians to develop diagnosis, prevention and further treatment.

以文找文

期刊論文
1.	Gandevia, S. C.(200110)。Spinal and Supraspinal Factors in Human Muscle Fatigue。Physiological Reviews，81(4)，1725-1789。
2.	Chiu, Tai-Yuan、Hu, Wen-Yu、Chen, Ching-Yu(2000)。Prevalence and severity of symptoms in terminal cancer patients: a study in Taiwan。Supportive Care in Cancer，8(4)，311-313。
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4.	Schubert, C.、Hong, S.、Natarajan, L.、Mills, P. J、Dimsdale, J. E.(2007)。The association between fatigue and inflammatory marker levels in cancer patients: a quantitative review。Brain, Behavior, and Immunity,，21(4)，413-427。

其他
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