This study attempted to create the health-food packaging design by utilizing the principles of universal design and was conducted through four stages. Firstly, researchers analyzed domestic and foreign literature reviews related to Universal Design and then performed in-depth interviews with the elderly aged from 65 to 75 with a view to finding out any problems on packaging and using them as primary rules for design improvements. Thirdly, using the results obtained from the second stage, coupled with Universal Design principles, we carried out integrating, summarizing, and determining the principles of universal design for health food packaging. Finally, a cross-analysis of universal design principles with this finding from the experiment was conducted to attain specific conclusions of universal design that can be applied in health food packaging. The findings of this study are as follows. 1. Background packaging should be white or light colors. 2. Moderate use of color can increase the distinction of text and enhanced product texture. 3. Bright surface material and polishing-printing are not suitable in packaging. 4. Gold and silver color can be utilized to increase the packaging texture, under the condition of not affecting the graphic design for reading text. 5. The packaging caption should not be less than 7pt. 6. ＂Recommended dosage＂ is the most important message for instructions, and should be marked on the packaging front. The tit le font makes no statistic difference in packaging printing, as long as it is clearly printed. The glass bottle provides higher protection and safety for goods than plastic one. As to the height of the bottle and the sizes of the bottle and the cap, no statistic differences were found. However, the cap side should be preferably designed with friction for the elderly.