Although amendments to the Hospice Palliative Care Act stipulate that the life support provided to end-of-life patients may be withdrawal on the premise that patients’ wishes and their autonomy in medical treatment decisions are fulfilled. However, such stipulation is difficult to implement in practice because health professionals often believe that withdrawal life support is a positive action that causing patient death. This belief typically elicit sense of guilt in these health professionals. Consequently, few investigations have focused on cases of life support withdrawal. This study presents a case report of a nursing experience in caring for a end-of-life ICU patient who chose to withdrawal from life support. The author collected data through observations, physical assessments, and interview with family members, using the Gordon's Functional Health Patterns as a guideline. The case patient was determined to have experienced the following problems: acute pain; spiritual distress and expectant grievance among family members. Providing individualized nursing measures to the case patient alleviated the pain and discomfort in the patient, encouraged the patient to express the spiritual distress regarding death, and assisted the patient in preparing for a peaceful death, physically, mentally, and spiritually. Regarding the expectant grievance among family members, by listening to them, accompanying them, and imparting words of religious beliefs, family members were guided to prepare for and accept death. Through this process, family members could eventually express their feelings, thus fulfilling the four principles of life (love, gratitude, forgiveness, and grace in bidding farewell). This case report can serve as a reference for health care professionals when caring for end-of-life patients who choose to withdrawal from life support.